Kim J-YV, Lee B, Koitsopoulos P, Shannon CP, Chen V, Hollander Z, Assadian S, Lam K, Ritchie G, McManus J, McMaster WR, Ng RT, McManus BM, Tebbutt SJ. Analytical Validation of HEARTBiT: A Blood-Based Multiplex Gene Expression of Profiling Assay for Exclusionary Diagnosis of Acute Cellular Rejection in Heart Transplant Patients. Clinical Chemistry, Volume 66, Issue 8, August 2020, DOI: 10.1093/clinchem/hvaa123

Zhou Q, Wei X-S, Xiang X, Wang Z, Chen V, Shannon CP, Tebbutt SJ, Kollmann TR, Fish EN. Interferon-a2b treatment for COVID-19. Front. Immunol., 15 May 2020 | https://doi.org/10.3389/fimmu.2020.01061


Shannon CP, Hollander Z, Dai DLY, Chen V, Assadian S, Lam KL, McManus JE, Zarzycki M, Kim Y, Kim J-YV, Balshaw R, Gidlof O, Ohman J, Smith JG, Toma M, Ignaszewski A, Davies RA, Delgado D, Haddad H, Isaac D, Kim D, Mui A, Rajda M, West L, White M, Zieroth S, Tebbutt SJ, Keown PA, McMaster WR, Ng RT, McManus BM. HEARTBiT: A Transcriptomic Signature for Excluding Acute Cellular Rejection in Adult Heart Allograft Patients. Canadian Journal of Cardiology 2019. doi:10.1016/j.cjca.2019.11.017.

Takiguchi H, Chen V, Obeidat M, Hollander Z, FitzGerald JM, McManus BM, Ng RT, Sin DD. Effect of short-term oral prednisone therapy on blood gene expression: a randomised controlled clinical trial.a Respir Res. 2019 Aug 5;20(1):176. doi: 10.1186/s12931-019-1147-2.

Singh A, He M, Chen V, Hollander Z, Tebbutt SJ, Ng RT, McManus BM, Sin DD, Ratjen F, Quon BS. Blood biomarkers to predict short-term pulmonary exacerbation risk in children and adolescents with CF: A pilot study. J Cyst Fibros. 2019 Jun 5. pii: S1569-1993(19)30774-X. doi: 10.1016/j.jcf.2019.05.020.

Alotaibi NM, Chen V, Hollander Z, Leipsic JA, Hague CJ, Murphy DT, DeMarco ML, FitzGerald JM, McManus BM, Ng RT, Sin DD. Phenotyping and outcomes of hospitalized COPD patients using rapid molecular diagnostics on sputum samples. Int J Chron Obstruct Pulmon Dis. 2019 Jan 23;14:311-319. doi: 10.2147/COPD.S188186. eCollection 2019.

Pesenacker AM, Chen V, Gillies J, Speake C, Marwaha AK, Sun A, Chow S, Tan R, Elliott T, Dutz JP, Tebbutt SJ, Levings MK. Treg gene signatures predict and measure type 1 diabetes trajectory. JCI Insight. March 21, 2019. doi.org/10.1172/jci.insight.123879

Singh A, Dai DLY, Ioannou K, Chen V, Lam KK, Hollander Z, Wilson-McManus JE, Assadian S, Toma M, Ng R, Virani S, Ignaszewski A, Tebbutt S, Bennett M, McManus BM. Ensembling Electrical and Proteogenomics Biomarkers for Improved Prediction of Cardiac-related 3-month Hospitalizations: A Pilot Study. Can J Cardiol. 2019 Apr;35(4):471-479. doi: 10.1016/j.cjca.2018.12.039. Epub 2019 Jan 4.


Wu D, Han JM, Yu X, Lam AJ, Hoeppli RE, Pesenacker AM, Huang Q, Chen V, Speake C, Yorke E, Nguyen N, Sampath S, Harris D, Levings MK. Characterization of regulatory T cells in obese omental adipose tissue in humans. Eur J Immunol. 2018 Dec 19. DOI: 10.1002/eji.201847570.

Alotaibi NM, Chen V, Hollander Z, Hague CJ, Murphy DT, Leipsic JA, DeMarco ML, FitzGerald JM, McManus BM, Ng RT, Sin DD. Phenotyping COPD exacerbations using imaging and blood-based biomarkers. International Journal of Chronic Obstructive Pulmonary Disease. 2018 January 8. DOI: 10.2147/COPD.S152484

Jin Z, Collier TS, Dai DLY, Chen V, Hollander Z, Ng RT, McManus BM, Balshaw R, Apostolidou S, Penn MS, Bystrom C. Development and Validation of Apolipoprotein AI-Associated Lipoprotein Proteome Panel for the Prediction of Cholesterol Efflux Capacity and Coronary Artery Disease. Clinical Chemistry. 2018 November 21. pii:clinchem.2018.291922doi: 10.1373/clinchem.2018.291922.

Leitao Filho FS, Alotaibi NM, Ngan D, Tam S, Yang J, Hollander Z, Chen V, Fitzgerald JM, Nislow C, Leung JM, Man SFP, Sin DD. Sputum Microbiome is Associated with 1-Year Mortality Following COPD Hospitalizations. Am J Respir Crit Care Med. 2018 October 30. DOI: 10.1164/rccm.201806-1135OC.


Obeidat M, Nie Y, Chen V, Shannon CP, Andiappan AK, Lee B, Rotzschke O, Castaldi PJ, Hersh CP, Fishbane N, Ng R, McManus B, Miller BE, Rennard S, Paré PD, Sin DD. Network-Based Analysis Reveals Novel Gene Signatures in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease. Respir Res. 2017 Apr 24;18(1):72. DOI: 10.1186/s12931-017-0558-1

Chen RY, Chen V, Hollander Z, Leipsic JA, Hague CJ, DeMarco ML, FitzGerald JM, McManus BM, Ng RT, Sin DD. C-reactive Protein and N-Terminal Prohormone Brain Natriuretic Peptide as Biomarkers in Acute Exacerbations of COPD Leading to Hospitalizations. PLoS One. 2017 Mar 22;12(3):e0174063. DOI: 10.1371/journal.pone.0174063

Toma M, Mak GJ, Chen V, Hollander Z, Shannon CP, Lam KKY, Ng RT, Tebbutt SJ, Wilson-McManus JE, Ignaszewski A, Anderson T, Dyck JRB, Howlett J, Ezekowitz J, McManus BM,Oudit GY. Differentiating heart failure phenotypes using sex-specific transcriptomic and proteomic biomarker panels. ESC Heart Failure. 2017 March. DOI: 10.1002/ehf2.12136

Sharma A, Kirkpatrick G, Skolnik K, Chen V, Hollander Z, Wilcox P, Quon BS. Clinical utility of C-reactive protein to predict treatment response during cystic fibrosis pulmonary exacerbations. PLoS One. 2017 Feb 8;12(2):e0171229. DOI: 10.1371/journal.pone.0171229

Shannon CP, Balshaw R, Chen V, Hollander Z, Toma M, McManus BM, Fitzgerald JM, Sin DD, Ng RT, Tebbutt SJ. Enumerateblood – an R package to estimate the cellular composition of whole blood from Affymetrix Gene ST gene expression profiles. BMC Genomics. 2017 Jan 6;18(1):43. DOI: 10.1186/s12864-016-3460-1


Shannon CP, Chen V, Takhar M, Hollander Z, Balshaw R, McManus BM, Tebbutt SJ, Sin DD, Ng RT. SABRE: a method for assessing the stability of gene modules in complex tissues and subject populations. BMC Bioinformatics. 2016 Nov 14;17(1):460.

Leung J, Chen V, Hollander Z, Dai D, Tebbutt S, Aaron SD, Vandemheen KL, Rennard SI, FitzGerald MJ, Woodruff PG, Lazarus SC, Connett JE, Coxson HO, Miller B, Borchers CH, McManus BM, Ng RT, Sin DD. COPD Exacerbation Biomarkers Validated Using Multiple Reaction Monitoring Mass Spectrometry. PLoS One. 2016 Aug 15;11(8):e0161129. DOI: 10.1371/journal.pone.0161129

Meredith AJ, Dai DL, Chen V, Hollander Z, Ng R, Kaan A, Tebbutt S, Ramanathan K, Cheung A, McManus BM. Circulating biomarker responses to medical management vs. mechanical circulatory support in severe inotrope-dependent acute heart failure. ESC Heart Fail. 2016 Jun;3(2):86-96. DOI: 10.1002/ehf2.12076


Obeidat M, Fishbane N, Nie Y, Chen V, Hollander Z, Tebbutt SJ, et al. (2015) The Effect of Statins on Blood Gene Expression in COPD. PLoS ONE 10(10): e0140022. DOI:10.1371/journal.pone.0140022


Hollander Z, Lazarova M, Lam KKY, Ignaszewski A, Oudit GY, Dyck J, Schreiner G, Pauwels J, Chen V, Cohen Freue GV, Ng RT, Wilson-McManus J, Balshaw R, Tebbutt S, McMaster R, Keown PA, McManus BM. Proteomic Biomarkers of Recovered Heart Function. Eur J Heart Fail. 2014 May;16(5):551-9


Hollander Z, Chen V, Lin D, Ng R.T., Balshaw R, Cohen Freue G, Ignaszewski A, Imai C, Kaan A, Wilson-McManus J, McMaster R, Keown P, McManus BM. Predicting acute cardiac allograft rejection using donor and recipient gene expression. J Heart Lung Transplant. 2013 Feb; 32(2):259-65


Günther OP, Chen V, Cohen Freue G, Balshaw RF, Tebbutt SJ, Hollander Z, Takhar M, McMaster R, McManus BM, Keown PA, Ng R. A computational pipeline for the development of multi marker bio-signature panels and ensemble classifiers. BMC Bioinformatics. 2012 December; 13:326


Hollander Z, Lin D, Chen V, Ng R, Wilson-McManus J, Ignaszewski A, Cohen Freue G, Balshaw R, Mui A, McMaster R, Keown PA, McManus BM for the NCE CECR PROOF Centre of Excellence. Whole Blood Biomarkers of Acute Cardiac Allograft Rejection: Double-Crossing the Biopsy.Transplantation. 2010 Dec; 90(12):1388-93